No results found

Check the spelling or try searching for a more general term.

2RT, Retinal Rejuvenation

Retinal Rejuvenation – a restorative treatment breakthrough

A breakthrough treatment approach, Ellex 2RT™ - Retinal Rejuvenation Therapy - retains the therapeutic benefits of laser therapy whilst eliminating the thermal tissue damage inherent in conventional retinal photocoagulation. 2RT™ is Ellex’s proprietary nanosecond laser therapy that stimulates a natural, biological healing response in the eye to slow the degenerative processes that cause retinal disease, including AMD.

Related products

Related conditions

Main Image Landing Retinal Rejuvenation
Image courtesy of Erica Fletcher, MD, PhD

Gentle stimulation, natural renewal

Retinal Rejuvenation Therapy stimulates a biological healing process that results in cellular rejuvenation, renewing the entire transport mechanism of the retina and improving the hydraulic conductivity of Bruch’s Membrane. In suitable patients, this rejuvenation process preserves or improves functional vision and reduces disease progression.

Ellex 2RT™ utilizes an ultra-short nanosecond laser pulse that allows the precise and specific delivery of laser energy to nano-sized targets within the cellular structure of ageing RPE cells – without causing collateral damage to the overlying photoreceptor rods and cones of the retina.

  • 2RT™ utilizes Nanopix™ Technology comprising solid-state nanosecond laser technology and a pixelated beam profile.
  • 2RT™ induces a mononuclear cell response in the treatment of early AMD, including the stimulation of microglia.
  • 2RT™ eliminate the incidence of heat damage to the retina and surrounding cells in the treatment of CSME.

Changing the paradigm for AMD 

Until now, therapies for Age-Related Macular Degeneration (AMD) have only focused on late stage treatments that attempt to manage the symptoms experienced by patients — by which stage vision loss, and or damage has already occurred.

Currently, the sole option for the more aggressive wet form of AMD is the administration of expensive and invasive anti-VEGF injections. These are only suitable for advanced or end stage disease, and merely address complications associated with AMD.

In contrast, 2RT™ Retinal Rejuvenation Therapy enables ophthalmologists the potential to intervene earlier in the disease process with the aim of slowing the degeneration process.

Clinically proven to delay progression to late-stage AMD in selected patients.

The Laser Intervention in Early AMD (LEAD) clinical trial, a large randomized, controlled clinical trial, has demonstrated the potential for 2RT™ to significantly reduce the rate of disease progression in a specific group of intermediate AMD patients. The trial, which enrolled 292 patients, examined whether the application of 2RT™ could delay progression of intermediate AMD to late-stage disease. Each participant was randomly assigned to 2RT™ treatment, or a sham laser procedure (placebo group) and received treatment and/or follow-up over three years.

Despite not reaching statistical significance, when considering all patients enrolled in the trial, there was a trend to delay progression from early to late stage AMD in those treated with 2RT™ Retinal Rejuvenation Therapy.

Post hoc analyses showed that in patients who did not have coexistent reticular pseudodrusen (RPD), a fatty deposit that is associated with later stages of AMD (76% of patients enrolled), treatment with 2RT™ resulted in a clinically meaningful 77% reduction in the rate of disease progression.


1. Guymer RH, Wu Z, Hodgson LAB, et al. Sub-Threshold Nanosecond Laser Intervention in Age-Related Macular Degeneration: The LEAD Randomized Controlled Clinical Trial. Ophthalmology. 2018. *Post hoc analysis in patients without coexistent reticular pseudodrusen (RPD).

Taking the heat out of photocoagulation

For Diabetic Macular Edema and Proliferative Retinopathy, CW retinal photocoagulation remains a mainstream pathway. The use of CW photocoagulation to treat retinal disease represents a two-fold challenge. First — the treatment causes irreversible collateral damage to retinal tissue, and, second — it is an often painful procedure for the patient. 

Clinical studies have shown 2RT™ can deliver a therapeutic benefit for the treatment of Clinically Significant Macular Edema (CSME) similar to that achieved through thermal retinal photocoagulation laser treatment, but without the collateral damage associated with the conventional method. Using 500 times less energy than retinal photocoagulation, 2RT™ eliminates the incidence of heat damage to the retina and surrounding cells.1

“… if we can slow down the basal rate of Bruch’s Membrane aging with 2RT™ and restore function to what it was when the patient was in their teens, we should be able to significantly delay AMD onset.”

1. Guymer RH, Wu Z, Hodgson LAB, et al. Sub-Threshold Nanosecond Laser Intervention in Age-Related Macular Degeneration: The LEAD Randomized Controlled Clinical Trial. Ophthalmology. 2018.

2.  Casson RJ. Et al., “Pilot randomized trial of a nanopulse retinal laser versus conventional photocoagulation for the treatment of diabetic macular oedema”, Clin Experiment Ophthalmol. 2012 Aug;40(6):604-10

Contact us

2RT has a CE Mark (Conformité Européene) for treatment in patients with early AMD where it can produce bilateral improvements in macular appearance and function.

2RThas a CE Mark (Conformité Européene) and US Food and Drug Administration (FDA) (510k) Market release for the treatment of Clinically Significant Macula Edema (CSME).

2RT is not approved for sale in the USA for the indication of early AMD.

This website uses cookies to ensure you get the best experience on our website.
The cookies do not store any personalised information. Learn More