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2RT, Retinal Rejuvenation

Retinal Rejuvenation – a restorative treatment breakthrough

A breakthrough treatment approach, Ellex 2RT™ - Retinal Rejuvenation Therapy - retains the therapeutic benefits of laser therapy whilst eliminating the thermal tissue damage inherent in conventional retinal photocoagulation. 2RT™ is Ellex’s proprietary nanosecond laser therapy that stimulates a natural, biological healing response in the eye to slow the degenerative processes that cause retinal disease.

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Main Image Landing Retinal Rejuvenation
Image courtesy of Erica Fletcher, MD, PhD

Gentle stimulation, natural renewal

Retinal Rejuvenation Therapy stimulates a biological healing process that results in cellular rejuvenation, renewing the entire transport mechanism of the retina and improving the hydraulic conductivity of Bruch’s Membrane. In suitable patients, this rejuvenation process preserves or improves functional vision and reduces disease progression.

Ellex 2RT™ utilizes an ultra-short nanosecond laser pulse that allows the precise and specific delivery of laser energy to nano-sized targets within the cellular structure of ageing RPE cells – without causing collateral damage to the overlying photoreceptor rods and cones of the retina.

  • 2RT™ utilizes Nanopix™ Technology comprising solid-state nanosecond laser technology and a pixelated beam profile.
  • 2RT™ eliminate the incidence of heat damage to the retina and surrounding cells in the treatment of CSME.

Taking the heat out of photocoagulation

For Diabetic Macular Edema and Proliferative Retinopathy, CW retinal photocoagulation remains a mainstream pathway. The use of CW photocoagulation to treat retinal disease represents a two-fold challenge. First — the treatment causes irreversible collateral damage to retinal tissue, and, second — it is an often painful procedure for the patient. 

Clinical studies have shown 2RT™ can deliver a therapeutic benefit for the treatment of Clinically Significant Macular Edema (CSME) similar to that achieved through thermal retinal photocoagulation laser treatment, but without the collateral damage associated with the conventional method. Using 500 times less energy than retinal photocoagulation, 2RT™ eliminates the incidence of heat damage to the retina and surrounding cells.1

1.  Casson RJ. Et al., “Pilot randomized trial of a nanopulse retinal laser versus conventional photocoagulation for the treatment of diabetic macular oedema”, Clin Experiment Ophthalmol. 2012 Aug;40(6):604-10

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2RT has a CE Mark (Conformité Européene) for treatment in patients with early AMD where it can produce bilateral improvements in macular appearance and function.

2RThas a CE Mark (Conformité Européene) and US Food and Drug Administration (FDA) (510k) Market release for the treatment of Clinically Significant Macula Edema (CSME).

2RT is not approved for sale in the USA for the indication of early AMD.

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